GliSODin®, the first orally effective superoxide dismutase, is the revolutionary, 100% vegetarian
A Health Promoting and Anti-Aging Nutraceutical Product
Nutraceutical Applications
Immunity, Oxidative stress & Pharmacology Immunity
Oxidative Stress

Superoxide Dismutase (SOD):
Among anti-oxidants, the Superoxide Dismutase (SOD) enzyme family (4,5) appears to be the most potent system to revitalize and reduce the rate of cell destruction. It promotes the removal of the super-oxide anion free radical by dismutation and therefore constitutes an important system for protecting cells and tissues against degeneration and death.
Zinc and copper also aid the body’s utilization of SOD. SOD levels tend to decline with age, while free radical production increases. Supplemental SOD’s potential as an anti-aging treatment is currently being explored.
There are three chemical variants of this enzyme in mammals. The two copper/zinc forms are the cytoplasmic and the extracellular Cu/Zn-SOD. These two kinds of Cu/Zn-SOD neutralize the production of free radicals resulting from normal and/or adaptive metabolic activities that take place in the cytoplasm of the cells and in other biological fluids. The manganese form (Mn-SOD) is active in the mitochondria, organelles within the cells where energy is produced.
SOD occurs naturally in barley grass, broccoli, brussel sprouts, cabbage, wheat grass, melon and most green plants. Bovine-derived SOD has also been used as a therapeutic agent, and it is also available in nutritional supplement forms. However, to produce health effects, SOD nutritional supplements must be protected against the digestive process in the stomach. In addition, it must be absorbed in its native form at the small intestine to elicit its pharmacological properties.
GliSODin® : the first SOD deliverable by the oral route
SOD’s are proteins with very specific shapes that determine the enzyme's function. When exposed to the acidic environment of the stomach and to digestive enzymes, SOD’s lose their specific shape, destroying its functionality. This is why it has been difficult to produce an oral SOD active nutritional supplement (6).
These anti-oxidant enzymes have now been coated in a protective vegetal prolamine (wheat gliadin) layer that not only prevents the stomach’s digestion but also promotes the delivery of the bioactive molecule in the small-intestine mucosa (patent FR 2 729 296, WO 96 21 462: EP 804 225, US 6 045 809 and JP 520 616).
Orally deliverable SOD is manufactured by combining a vegetarian source of SOD with a wheat-based biopolymer (gliadin). Orally deliverable SOD is the first functional health food SOD delivered by the oral route that vitalizes the body’s anti-oxidant activity.
· GliSODin® formula:
GliSODin® (in 100 g)
Mineral content 0.05 g
Carbohydrates 91.6 g
Protein 2.6 g

· Class:
Anti-oxidant
Anti-inflammatory
Immuno-regulatory

· Dosage
GliSODin® : 250 mg two times daily, taken with meals